儿童清肺糖浆制备工艺研究
时间：2021-02-05 08:01:02 来源：雅意学习网 本文已影响 人 
[摘要] 目的 研究儿童清肺糖浆的最佳生产工艺条件。 方法 对剂型选择、提取工艺路线及制剂工艺技术等方面进行考察。 结果 儿童清肺糖浆的最佳生产工艺条件为取处方量橘红、炒紫苏子、紫苏叶、薄荷、前胡、石菖蒲等6味药加12倍量水浸泡3 h后，用水蒸气蒸馏法提取3 h，收集挥发油，药液滤过，备用。其余黄芩等16味药加8倍量水提取3次，每次1 h，药液滤过。全部药液合并后，减压浓缩至相对密度1.03～1.05（40～50℃），放冷，滤过。滤液加入蔗糖600 g，山梨酸钾2 g，对羟基苯甲酸乙酯0.2 g，加热搅拌使溶解，煮沸30 min，放冷，滤过。取挥发油用少量乙醇溶解后加入滤液中，充分搅拌，加入纯化水至1000 ml，搅拌均匀，分装成瓶，即得。 结论 优选的儿童清肺糖浆生产工艺，既保证了产品质量，又适合儿童服用，并降低了生产成本，适合于工业化大生产。
[关键词] 清肺糖浆；正交试验；生产工艺；儿童
[中图分类号] R461 [文献标识码] A [文章编号] 1674-4721（2016）02（b）-0007-04
Study on preparation technology of Children technology research
GUO Jin-jia1，2 DANG Xiao-wei3 LI Jun1，2 ZHANG Guang-xing1
1.Jingfukang Pharmaceutical Group Company Limited，Hebei Province，Chengde 067000，China；2.The New Excipients of Traditional Chinese Medicine Engineering Research Center of Hebei，Hebei Province，Chengde 067000，China；3.Chengde Nursing Vacationgnal College，Hebei Province，Chengde 067000，China
[Abstract] Objective To study on optimum technological conditions for Clearing Lung Syrup for children. Methods The extraction technology， preparation selection and pharmaceutical technology were studied. Results The preparation method for Clearing Lung Syrup for children inclusion complex was got prescriptions of dried tangerine peel， roasted perilla seed， folia perillae acutae， mint， common hogfenneI root， rhizoma acori graminei with the amount of water or 12 times，and the soaking time was 3 h then extracted by wet distillation for 3 h.Volatile oil was collected and the extraction fluid was filtered to reserve. The other 16 herbs was extracted three times in water 8 times， filtrated， and the filtrate was combined with the former. The mixed decoction was concentrated to 1.03～1.05（40～50℃），set cold， filtrated， and was ensiled with suger 600 g，potassium sorbate 2 g and ethyl P-Hydroxybenzoate 0.2 g，heated and stirred， boiled for 30 min， set cold， filtrated. Volatile oil was dissolved by a few ethanol with efficient stirring， add provision to purify water volume of 1000 ml， juice， filtering， rebottling into small bottles. Conclusion The optimal processing condition not only can ensure the product quality and its suitable for children patients but also reduce cost. It apply to industrial production.
[Key words] Clearing Lung Syrup；Extraction technology；Production process；Children
儿童清肺糖浆系儿童清肺丸改剂型品种，儿童清肺丸为《中国药典》一部收载品种，由麻黄、炒苦杏仁、石膏、甘草、蜜桑白皮等22味中药组成，具有清肺、解表、化痰、止嗽之功效[1]。现代药理研究表明，儿童清肺丸具有抑菌、解热、抗炎、镇咳、化痰的药理作用[2]。原丸剂剂型为全部药材细粉直接入药，有效成分释放慢，生物利用度低，且味苦、辛辣，入口难咽，使儿童难以接受。儿童清肺糖浆是在原剂型的基础上，经合理的提取纯化工艺，制成糖浆剂剂型，具有口感好、见效快、生物利用度高等特点，儿童服用方便，易于接受。因此，研究儿童清肺糖浆的工艺生产路线具有一定的应用价值。
